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Ak-42

AOB14600

CAS 15437-29-3

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Novel potent and specific inhibitor of CLC-2 (IC50 = 17 ± 1 nM), displaying unprecedented selectivity (>1,000-fold) over CLC-1, the closest CLC-2 homolog, and exhibiting no off-target engagement against a panel of 61 common channels, receptors, and transporters expressed in brain tissue