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Siais164018

AOB12320

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Novel Brigatinib PROTAC degrader, degrading not only ALK fusion proteins in activating G1202R-mutated form but also mutant EGFR with L858R + T790M as well as several important oncoproteins involved in metastasis such as FAK, PYK2, and PTK6, strongly inhibiting cell migration and invasion of Calu-1 and MDA-MB-231