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Rb-3

AOB12274

CAS 2396639-11-3

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Novel inhibitor of polycomb repressive complex 1 (PRC1), directly binding to RING1B-BMI1, the heterodimeric complex constituting the E3 ligase activity of PRC1, blocking the association of RING1B-BMI1 with chromatin and inhibiting H2A ubiquitination, leading to a reduction in H2Aub and differentiation in TEX cells