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Xist Ligand X1 View larger

Xist Ligand X1

AOB16542

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Novel non-coding RNA prototype Xist ligand, specifically binding the RepA motif of Xist, reducing the conformational space of RepA, displacing cognate interacting protein factors (PRC2 and SPEN), suppressing histone H3K27 trimethylation, and blocking initiation of X-chromosome inactivation