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TFMB-(R)-2-HG
AOB2854
CAS No: 1445700-01-5
Chemical Name: (2R)-Tetrahydro-5-oxo-2-furancarboxylic acid [3-(trifluoromethyl)phenyl]methyl ester
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $12.24 | Total: $1,224.00 |
| 1 | 50 | $14.14 | Total: $707.20 |
| 1 | 25 | $16.59 | Total: $414.80 |
| 1 | 10 | $19.58 | Total: $195.84 |
| 1 | 5 | $23.12 | Total: $115.60 |
Data sheet
| Molecular Formula | C13H11F3O4 |
| Molecular Weight | 288.22 |
| CAS Numbers | 1445700-01-5 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | (2R)-tetrahydro-5-oxo-2-furancarboxylic acid, [3-(trifluoromethyl)phenyl]methyl ester |
| InChl Key | UXTLNUGKDZMPTC-SNVBAGLBSA-N |
| InChl Code | InChI=1S/C13H11F3O4/c14-13(15,16)9-3-1-2-8(6-9)7-19-12(18)10-4-5-11(17)20-10/h1-3,6,10H,4-5,7H2/t10-/m1/s1 |
| SMILES Code | O=C([C@H]1CCC(O1)=O)OCC2=CC=CC(C(F)(F)F)=C2 |
| References | 1) Losman, J.A., Looper, R.E., and Koivunen, P. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science 339(6127), 1621-1625 (2013). 2) Yang, H., Ye, D., Guan, K.L., et al. IDH1 and IDH2 mutations in tumorigenesis: Mechanistic insights and clinical perspectives. Clin. Cancer Res. 18(20), 5562-5571 (2012). |
More info
Cell membrane-permeable version of (R)-2-HG as a promoter of leukemogenesis, dose-dependently and passage-dependently blocking differentiation
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