Cytokine Receptors

TFMB-(R)-2-HG View larger

TFMB-(R)-2-HG

AOB2854

CAS No: 1445700-01-5

 

Chemical Name: (2R)-Tetrahydro-5-oxo-2-furancarboxylic acid [3-(trifluoromethyl)phenyl]methyl ester

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$27.20

$27.20 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $12.24 Total: $1,224.00
150 $14.14 Total: $707.20
125 $16.59 Total: $414.80
110 $19.58 Total: $195.84
15 $23.12 Total: $115.60

Data sheet

Molecular FormulaC13H11F3O4
Molecular Weight288.22
CAS Numbers1445700-01-5
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name(2R)-tetrahydro-5-oxo-2-furancarboxylic acid, [3-(trifluoromethyl)phenyl]methyl ester
InChl KeyUXTLNUGKDZMPTC-SNVBAGLBSA-N
InChl CodeInChI=1S/C13H11F3O4/c14-13(15,16)9-3-1-2-8(6-9)7-19-12(18)10-4-5-11(17)20-10/h1-3,6,10H,4-5,7H2/t10-/m1/s1
SMILES CodeO=C([C@H]1CCC(O1)=O)OCC2=CC=CC(C(F)(F)F)=C2
References1) Losman, J.A., Looper, R.E., and Koivunen, P. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science 339(6127), 1621-1625 (2013).

2) Yang, H., Ye, D., Guan, K.L., et al. IDH1 and IDH2 mutations in tumorigenesis: Mechanistic insights and clinical perspectives. Clin. Cancer Res. 18(20), 5562-5571 (2012).

More info

Cell membrane-permeable version of (R)-2-HG as a promoter of leukemogenesis, dose-dependently and passage-dependently blocking differentiation

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