DA Receptors

(+)-Butaclamol Hydrochloride View larger

(+)-Butaclamol Hydrochloride

AOB5859

CAS No: 55528-07-9

Chemical Name: 1H-Benzo[6,7]cyclophepta [1,2,3-de]-pyrido[2,1-a]isoquinolin-3-(l, 3-(1,1-dimethylethyl)-2,3-4,4a,8,9,13b,14-octahydro-hydrochloride (3a,4aa, 13b b)

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $6.75 Total: $675.00
150 $7.80 Total: $390.00
125 $9.15 Total: $228.75
110 $10.80 Total: $108.00
15 $12.75 Total: $63.75

Data sheet

Molecular FormulaC25H31NO · HCl
Molecular Weight397.98
CAS Numbers55528-07-9
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilitySoluble in water (0.25 mg/ml) or ethanol (1 mg/ml); more soluble in alcohol-water mixtures. Dissolve solid in alcohol and dilute with water. Solubility in 45% (w/v) aqueous 2-hydroxypropyl-b-cyclodextrin 5.4 mg/ml. Solutions should be freshly prepared.
Purity98% by HPLC

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Dopamine receptor antagonist

References:

  1. Merck Index11th Ed., No. 1499
  2. Brunderlein, et al., J. Med. Chem.v. 18, 185 (1975)
  3. Humber, L.G., Bruderlein, F.T., Voith, K., "Neuroleptic agents of the benzocycloheptapyrido-soquinoline series: a hypothesis on their mode of interaction with the central dopamine receptor." Mol. Pharmacol.v. 11, 833-840 (1975)
  4. Humber, L.G., "Butaclamol." Chronicles of Drug DiscoveryVol. 1, Chap. 3, 61 (1982)
  5. Lippman, et al., Psychopharmacologiav. 42, 11 (1975)
  6. Lippman, et al., "Effect of butaclamol and its enantiomers upon striatal homovanillic acid and adenyl cyclase of olfactory tubercle in rats." Life Sci.v. 16, 213-224 (1975).
  7. Mielke, et al., Dis. Nerv. Syst.v. 36, 7 (1975)
  8. Mineeva, et al., "Effect of butaclamol enantiomers or tyrosine hydroxylase of the rat brain hypothalamus." [CA 102(3): 17545D] Byull. Eksp. Biol. Med.v. 98, 453 (1984)
  9. Pugsley, et al., "Effect of structural analogs of butaclamol (a new antipsychotic drug) on striatal homovanillic acid and adenyl cyclase of olfactory tubercle in rats." J. Physiol. Pharmacol.v. 54, 510-515 (1976).
  10. Pugsley, T.A. and Lippman, W., "Effect of butaclamol, a new neuroleptic on serotonergic mechanisms." J. Pharm. Pharmacol.v. 29, 135-138 (1977).
  11. Seeman, Pharmacological Reviewsv. 32, 229 (1980)
  12. Steranka, "Effects of antipsychotic drugs on the long-term effects of amphetamine on nigrostriatal dopamine neurons in iprinodole-treated rats." Naunyn-Schmiedeberg's Arch. Pharmacol.v. 325, 198 (1984)
  13. Voith, et al., Life Sci.v. 16, 213 (1975)

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