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> G Protein-Coupled Receptor Ligands>EAA Receptors>MK-3903

EAA Receptors

MK-3903 View larger

MK-3903

AOB33326

CAS: 1219737-12-8

Chemical Name: 5-((5-([1,1"-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $41.65 Total: $208.25
110 $35.28 Total: $352.80
125 $29.89 Total: $747.25
150 $25.48 Total: $1,274.00
1100 $22.05 Total: $2,205.00

Data sheet

Molecular FormulaC26H31N3O
Molecular Weight401.55
CAS Numbers280783-56-4
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymMK-3903; MK 3903; MK3903.
IUPAC/Chemical Name5-[(5-[1,1′-biphenyl]-4-yl-6-chloro-1H-benzimidazol-2-yl)oxy]-2-methyl-benzoic acid
InChl KeyFIKQZQDYGXAUHC-UHFFFAOYSA-N
InChl CodeInChI=1S/C27H19ClN2O3/c1-16-7-12-20(13-21(16)26(31)32)33-27-29-24-14-22(23(28)15-25(24)30-27)19-10-8-18(9-11-19)17-5-3-2-4-6-17/h2-15H,1H3,(H,29,30)(H,31,32)
SMILES CodeClC(C=C(N=C(OC1=CC=C(C)C(C(O)=O)=C1)N2)C2=C3)=C3C(C=C4)=CC=C4C5=CC=CC=C5
References1) Lan, P., Romero, F.A., Wodka, D., et al. Hit-to-lead optimization and discovery of 5-((5-([1,1'-biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic acid (MK-3903): A novel class of benzimidazole-based activators of AMP-activated protein kinase. J. Med. Chem. 60(21), 9040-9052 (2017).

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Novel potent and selective AMPK activator