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> G Protein-Coupled Receptor Ligands>EAA Receptors>L-701324

EAA Receptors

L-701324 View larger

L-701324

AOB33755

CAS No:142326-59-8

Chemical Name: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenylquinolin-2[1H]-one

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$17.50

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $14.88 Total: $74.38
110 $12.60 Total: $126.00
125 $10.68 Total: $266.88
150 $9.10 Total: $455.00
1100 $7.88 Total: $787.50

Data sheet

Molecular FormulaC21H14ClNO3
Molecular Weight363.79
CAS Numbers142326-59-8
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity 99% (HPLC)
IUPAC/Chemical Name7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
InChl KeyFLVRDMUHUXVRET-UHFFFAOYSA-N
SMILES CodeOC1=C(C(=O)NC2=CC(Cl)=CC=C12)C1=CC=CC(OC2=CC=CC=C2)=C1
References1) Bristow et al (1996) Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-MthD.-aspartate receptor complex. J.Pharmacol.Exp.Ther. 279 492 PMID: 8930150

2) Kulagowski et al (1994) 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor. J.Med.Chem. 37 1402 PMID: 8182696
PubChem ID54682505

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Highly potent and selective antagonist at the glycine site of the NMDA glutamate receptor