Enzyme Inhibitors

ABX-1431 View larger

ABX-1431

AOB17733

CAS: 1446817-84-0

 

Chemical Name: 1,1,1,3,3,3-Hexafluoropropan-2-yl-4-[[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate

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$11.00

$11.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $4.95 Total: $495.00
50 $5.72 Total: $286.00
25 $6.71 Total: $167.75
10 $7.92 Total: $79.20
5 $9.35 Total: $46.75

Data sheet

Molecular FormulaC20H22F9N3O2
Molecular Weight507.40
CAS Numbers 1446817-84-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name1,1,1,3,3,3-Hexafluoropropan-2-yl-4-[[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate
InChl KeySQZJGTOZFRNWCX-UHFFFAOYSA-N
InChl CodeInChI=1S/C20H22F9N3O2/c21-18(22,23)14-4-3-13(15(11-14)31-5-1-2-6-31)12-30-7-9-32(10-8-30)17(33)34-16(19(24,25)26)20(27,28)29/h3-4,11,16H,1-2,5-10,12H2
SMILES CodeO=C(N1CCN(CC2=CC=C(C(F)(F)F)C=C2N3CCCC3)CC1)OC(C(F)(F)F)C(F)(F)F
References1) Jiang M, van der Stelt M. Activity-Based Protein Profiling Delivers Selective Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid Metabolism in Neurological Disorders. J Med Chem. 2018 Oct 25;61(20):9059-9061.

2) Cisar JS, Weber OD, Clapper JR, Blankman JL, Henry CL, Simon GM, Alexander JP,Jones TK, Ezekowitz RAB, O'Neill GP, Grice CA. Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders. J Med Chem. 2018 Oct 25;61(20):9062-9084

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Novel Selective Inhibitor of Monoacylglycerol Lipase (MGLL)