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> Pathway Inhibitors>Enzyme Inhibitors>JNJ-64619178 (Onametostat)

Enzyme Inhibitors

JNJ-64619178 View larger

JNJ-64619178 (Onametostat)

AOB17663

CAS: 2086772-26-9

 

Chemical Name: (1S,2R,3S,5R)-3-(2-(2-Amino-3-bromoquinolin-7-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol; Onametostat

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$49.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $41.65 Total: $208.25
110 $35.28 Total: $352.80
125 $29.89 Total: $747.25
150 $25.48 Total: $1,274.00
1100 $22.05 Total: $2,205.00

Data sheet

Molecular FormulaC22H23BrN6O2
Molecular Weight483.37
CAS Numbers2086772-26-9
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymOnametostat
IUPAC/Chemical Name(1S,2R,3S,5R)-3-(2-(2-Amino-3-bromoquinolin-7-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
InChl KeyDBSMLQTUDJVICQ-CJODITQLSA-N
InChl CodeInChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-11(7-16(12)28-21(15)25)2-4-13-9-17(19(31)18(13)30)29-6-5-14-20(24)26-10-27-22(14)29/h1,3,5-8,10,13,17-19,30-31H,2,4,9H2,(H2,25,28)(H2,24,26,27)/t13-,17+,18+,19-/m0/s1
SMILES CodeBrC1=C(N)N=C(C=C(CC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1
References1) Tongfei Wu, et al. Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models.

2) Tao H, et al. Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations. Chem Pharm Bull (Tokyo). 2019;67(4):382-388.

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Novel potent and selective PRMT5 inhibitor, demonstrating tumor regression in a biomarker-driven human small cell lung cancer

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