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AOB17663
CAS: 2086772-26-9
Chemical Name: (1S,2R,3S,5R)-3-(2-(2-Amino-3-bromoquinolin-7-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol; Onametostat
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Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
---|---|---|---|
1 | 100 | $22.05 | Total: $2,205.00 |
1 | 50 | $25.48 | Total: $1,274.00 |
1 | 25 | $29.89 | Total: $747.25 |
1 | 10 | $35.28 | Total: $352.80 |
1 | 5 | $41.65 | Total: $208.25 |
Molecular Formula | C22H23BrN6O2 |
Molecular Weight | 483.37 |
CAS Numbers | 2086772-26-9 |
Storage Condition | 0°C (short term), -20°C (long term), desiccated |
Solubility | DMSO |
Purity | 98% by HPLC |
Synonym | Onametostat |
IUPAC/Chemical Name | (1S,2R,3S,5R)-3-(2-(2-Amino-3-bromoquinolin-7-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol |
InChl Key | DBSMLQTUDJVICQ-CJODITQLSA-N |
InChl Code | InChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-11(7-16(12)28-21(15)25)2-4-13-9-17(19(31)18(13)30)29-6-5-14-20(24)26-10-27-22(14)29/h1,3,5-8,10,13,17-19,30-31H,2,4,9H2,(H2,25,28)(H2,24,26,27)/t13-,17+,18+,19-/m0/s1 |
SMILES Code | BrC1=C(N)N=C(C=C(CC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1 |
References | 1) Tongfei Wu, et al. Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models. 2) Tao H, et al. Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations. Chem Pharm Bull (Tokyo). 2019;67(4):382-388. |
Novel potent and selective PRMT5 inhibitor, demonstrating tumor regression in a biomarker-driven human small cell lung cancer