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> Pathway Inhibitors>Enzyme Inhibitors> J-113863

Enzyme Inhibitors

J-113863 View larger

J-113863

AOB9218

CAS: 353791-85-2

Chemical Name: J113863; UCB-35625; 2,7-Dichloro-N-[1-[[(1E)-cycloocten-1-yl]methyl]-1-ethylpiperidin-1-ium-4-yl]-9H-xanthene-9-carboxamide iodide

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $33.15 Total: $165.75
110 $28.08 Total: $280.80
125 $23.79 Total: $594.75
150 $20.28 Total: $1,014.00
1100 $17.55 Total: $1,755.00

Data sheet

Molecular FormulaC30H37Cl2IN2O2
Molecular Weight655.44
CAS Numbers353791-85-2
Storage Condition0°C (short term), -20°C (long term), desiccated
Solubility60 mg /mL in DMSO and 33 mg/mL in EtOH
Purity98% by HPLC
Synonym J113863; UCB-35625
IUPAC/Chemical Name1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide
InChl KeyFOAFBMYSXIGAOX-LQGGPMKRSA-N
SMILES CodeClC1=CC=C(OC(C=CC(Cl)=C3)=C3C2C(N[C@@H]4CC[N@@+](C/C5=C/CCCCCC5)(CC)CC4)=O)C2=C1.ClC6=CC=C(OC(C=CC(Cl)=C8)=C8C7C(N[C@H]9CC[N@+](C/C%10=C/CCCCCC%10)(CC)CC9)=O)C7=C6.[I-].[I-]
References1) Naya et al (2001) Design, synthesis, and discovery of a novel CCR1 antagonist. J.Med.Chem. 44 1429 PMID: 11311066

2) Amat et al (2006) Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo. Br.J.Pharmacol. 149 666 PMID: 17016504

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Potent and selective inhibitor of CCR1 and CCR3