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> Pathway Inhibitors>Enzyme Inhibitors>Z-VAD-FMK

Enzyme Inhibitors

Z-VAD-FMK View larger

Z-VAD-FMK

AOB5976

CAS: 187389-52-2

 

Chemical Name: Z-VAD(OMe)-FMK; Z-Val-Ala-Asp-fluoromethylketone Methyl Ester

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$49.00

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $41.65 Total: $208.25
110 $35.28 Total: $352.80
125 $29.89 Total: $747.25
150 $25.48 Total: $1,274.00
1100 $22.05 Total: $2,205.00

Data sheet

Molecular FormulaC32H34Cl3F2N3O2
Molecular Weight637.0
CAS Numbers67465-36-3 ( HCl)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymZ-VAD-FMK; Z VADFMK; ZVADFMK; Z-VAD(OMe)-FMK; Z-Val-Ala-Asp(OMe)-FMK;
IUPAC/Chemical Namemethyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoate
InChl KeyMIFGOLAMNLSLGH-QOKNQOGYSA-N
InChl CodeInChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
SMILES CodeO=C(OC)C[C@H](NC([C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)C(C)C)=O)C)=O)C(CF)=O
References1) Slee EA1, Zhu H, Chow SC et al. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem J. 1996 Apr 1;315 ( Pt 1):21-4.

2) Lawrence CP1, Chow SC. Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties. Toxicol Appl Pharmacol. 2012 Nov 15;265(1):103-12.

More info

Cell-permeable, Irreversible, Non-cytotoxic Pan Caspase Inhibitor