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PHA-767491 hydrochloride
AOB8532
CAS: 942425-68-5
Chemical Name: 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $4.95 | Total: $495.00 |
| 1 | 50 | $5.72 | Total: $286.00 |
| 1 | 25 | $6.71 | Total: $167.75 |
| 1 | 10 | $7.92 | Total: $79.20 |
| 1 | 5 | $9.35 | Total: $46.75 |
Data sheet
| Molecular Formula | C12H12ClN3O |
| Molecular Weight | 249.7 |
| CAS Numbers | 942425-68-5 (HCl) |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | PHA767491; PHA-767491; PHA 767491; CAY10572; CAY-10572; CAY 10572. |
| IUPAC/Chemical Name | 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4 H -pyrrolo[3,2- c ]pyridin-4-one hydrochloride |
| InChl Key | IMVNFURYBZMFDZ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H |
| SMILES Code | O=C1C2=C(NC(C3=CC=NC=C3)=C2)CCN1.[H]Cl |
| References | 1) Li W, Zhao XL, Shang SQ, Shen HQ, Chen X. Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil. Curr Cancer Drug Targets. 2015;15(3):196-204. PubMed PMID: 25643258. 2) Sasi NK, Tiwari K, Soon FF, Bonte D, Wang T, Melcher K, Xu HE, Weinreich M. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9(11):e113300. doi: 10.1371/journal.pone.0113300. eCollection 2014. PubMed PMID: 25412417; PubMed Central PMCID: PMC4239038. |
More info
Potent, ATP-competitive dual cdc7/cdk9 inhibitor