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BMS-986158
AOB33413
CAS: 1800340-40-2
Chemical Name: (S)-2-(3-(1,4-Dimethyl-1H-1,2,3-triazol-5-yl)-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrido[3,2-b]indol-7-yl)propan-2-ol
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $26.55 | Total: $2,655.00 |
| 1 | 50 | $30.68 | Total: $1,534.00 |
| 1 | 25 | $35.99 | Total: $899.75 |
| 1 | 10 | $42.48 | Total: $424.80 |
| 1 | 5 | $50.15 | Total: $250.75 |
Data sheet
| Molecular Formula | C30H33N5O2 |
| Molecular Weight | 495.6 |
| CAS Numbers | 1800340-40-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO 50 mM |
| Purity | 98% by HPLC |
| Synonym | BMS-986158; BMS986158 |
| IUPAC/Chemical Name | 3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-α,α-dimethyl-5-[(S)-phenyl(tetrahydro-2H-pyran-4-yl)methyl]-5H-pyrido[3,2-b]indole-7-methanol |
| InChl Key | KGERZPVQIRYWRK-GDLZYMKVSA-N |
| InChl Code | InChI=1S/C30H33N5O2/c1-19-28(34(4)33-32-19)22-16-26-27(31-18-22)24-11-10-23(30(2,3)36)17-25(24)35(26)29(20-8-6-5-7-9-20)21-12-14-37-15-13-21/h5-11,16-18,21,29,36H,12-15H2,1-4H3/t29-/m1/s1 |
| SMILES Code | CC(O)(C)C(C=C1)=CC2=C1C(N=CC(C3=C(C)N=NN3C)=C4)=C4N2[C@H](C5=CC=CC=C5)C6CCOCC6 |
| References | 1) Gavai, A.V., Norris, D., Tortolani, D., et al. Abstract 5789: Discovery of clinical candidate BMS-986158, an oral BET inhibitor, for the treatment of cancer. Cancer Res. 78(13 Supplement), 5789-5789 (2018). |
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Novel potent and selective BET inhibitor