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voreloxin Hydrochloride
AOB4937
CAS: 175519-16-1
Chemical Name: Vosaroxin Hydrochloride; 7-[(3S,4S)-3-Methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,8-naphthyridine-3-carboxylic acid;hydrochloride
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $9.45 | Total: $945.00 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 5 | $17.85 | Total: $89.25 |
Data sheet
| Molecular Formula | C18H20ClN5O4S |
| Molecular Weight | 437.9 |
| CAS Numbers | 175519-16-1 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | 20 mg/mL (45.67 mM) |
| Purity | 98% by HPLC |
| Synonym | Vosaroxin Hydrochloride |
| IUPAC/Chemical Name | 7-[(3S,4S)-3-Methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,8-naphthyridine-3-carboxylic acid;hydrochloride |
| SMILES Code | CNC1CN(CC1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(=O)O.Cl |
| References | 1) Hotinski AK, et al. Vosaroxin is a novel topoisomerase-II inhibitor with efficacy in relapsed and refractory acute myeloid leukaemia. Expert Opin Pharmacother. 2015 Jun;16(9):1395-402. 2) Scatena CD, et al. Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8. |
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New-generation topo II inhibitor