Enzyme Inhibitors

Protein Control Ligand
Pathway Inhibitors
- Enzyme Inhibitors
- Protein Inhibitors
- Transporter Inhibitors
  - ATPases
- Cell Inhibition
- Synthase
- Receptor Tyrosine Phosphatases (RTP)
- AChE
- Peptidase
- Autophagy
- Toll-Like Receptor (TLR)
Function Modulators
- Potentiators
- Allosteric
- Votage-Gated Ion Channel Blockers
- Major Facilitator Superfamily (MFS) Transporters
- Ligand-Gated Ion Channels
- Aquaporins
- Chlorine Channels
- Connexins and Pannexins
- KCC2 - K-Cl co-transporter
- ADC cytotoxin
- ADC Linker
- CFTR
- CCK
- Monoamine Transporter
- Proton pump
Activators
- Receptor Activators
- Inducer
- Openers
- Potassium Channel
G Protein-Coupled Receptor Ligands
- 5HT Receptors
- Adrenoceptor
- Angiotensin Receptor
- Cannabinoid Receptors
- CCK Receptors
- DA Receptors
- EAA Receptors
- Ghrelin Receptors
- GABA Receptors
- Histamine Receptors
- Leukotriene Receptors
- Metabotropic Glutamate Receptors
- Motilin Receptors
- Muscarinic Receptor
- Neuropeptide Receptors
- Opioid Receptors
- Orexin Receptors
- Orphan Receptors
- Prostanoid Receptors
- Proteinase-Activated Receptors
- Purinergic Receptors
- Ryanodine receptor
- Sigma Receptors
- Thrombin Receptor
- Vaniloid Receptor
- VIP and PACAP Receptors
- Neurotensin Receptors
- Urotensin Receptor
- Imidazoline receptor
- SMO Receptors
- Apelin Receptor
- β-arrestin/β2-adaptin
- KDM4
- Glucocorticoid Receptor
- Laminin Receptor
- AHR
- Amylin Receptor
- Bombesin Receptor
- Bradykinin Receptor
- CFTR
- CGRP Receptor
- CRFR
- Endothelin Receptor
- Ephrin Receptor
- Farnesoid X receptor (FXR)
- Glucagon Receptor
Nuclear Receptor Ligands
- Retinoic Acid, X and Orphans Receptors
- Rev-Erb Receptors
- Hepatocyte Nuclear Factors Receptors
- COUP-TF Like Receptors
- Growth Factors Receptors
- Steroid Hormone Receptors
- DAX-Like Receptors
- Vitamin Related Receptors
- PPARs
- DNA Polymerase
- CRFR
- NOD
- RAAS
GDNF Receptors
TNF Receptors
Transcription Factors
Chemokines
- CXCR-2
- CXCR-3
- CXCR-4
- CXCR-7
Cytokine Receptors
- IL Receptors
- Interferon Receptors
- Integrins
- Toll-Like Receptors
- NOD-Like Receptors
Biomarkers and Buffer Solutions
- Universal DNA Markers
- Biological Buffers
- Biomarker
Molecular Probes
- Fluorescence Probes
- Chelating Agents
- Luminescent Probes
- Optical Probes
Stem Cell Research
- Reporter of Gene Expression
- CiPSC Cocktail
  - TSPC - CiPSC Cocktail
  - VC6TF - CiPSC Cocktail
- Complement System
Alzheimer's Disease
Apoptosis
Cancer Research
Epigenetics
Metabolites
PET/SPECT Imaging Precursors
Customized Screening Library
- Target Diversified Drug Like Small Molecule Library
- Target Focused Small Drug Like Molecule Library
Ultra Pure Pharmacological Standard
Tissue Microarray (TMA)
- Bladder
- Brain
- Breast
- Cervix
- Colon
- Digestive Sytem
- Esophagus
- Glucose Test Strips
- Kidney
- Large Intestine
- Liver
- Lung
- Lymphoma
- Multiple Organ
- Multiple Organ IFetus)
- Pancreas
- Prostate
- Rectum
- Reproductive System
- Stomach
- Thyroid
- Urological Sytem
Proteins and Antibodies
- Proteins and Enzymes
  - Cytokines and Chemokines
- Antibodies and Kits
  - RABBIT POLYCLONAL
  - RABBIT MONOCLONAL
- Protein Digestion Sufactant
- Cell Culture
Primary Cells
ELISA KIT
Natural Products
Lab Equipments
Humanized Mice for PDX Platform
Rare Chemicals
Custom Synthesis
Antibacterial
Antifungal
Antioxidant
Antiviral
Molecular Glues
PROTAC Linker
SARS-CoV

View larger

ML299

Cat No: AOB4530

Condition

CAS No: 1426916-00-8

Chemical Name: VU0463568; (S)-4-Bromo-N-(1-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)propan-2-yl)benzamide

More details

882 Item Items

Print Quotation

Molarity Calculation Cart^®

HOW TO ORDER

Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$25.08	Total: $125.38
1	10	$21.24	Total: $212.40
1	25	$18.00	Total: $449.88
1	50	$15.34	Total: $767.00
1	100	$13.28	Total: $1,327.50

Data sheet

Molecular Formula	C23H26BeFN4O2
Molecular Weight	489.38
CAS Numbers	1426916-00-8
Storage Condition	- 20C
Solubility	DMSO
Purity	98% by HPLC
Synonym	ML-299; ML 299; ML299; VU0463568; VU-0463568; VU 0463568.
IUPAC/Chemical Name	(S)-4-bromo-N-(1-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)propan-2-yl)benzamide
InChl Key	RFKXAYJUFUZBMA-INIZCTEOSA-N
InChl Code	InChI=1S/C23H26BrFN4O2/c1-16(27-21(30)17-5-7-18(24)8-6-17)14-28-11-9-23(10-12-28)22(31)26-15-29(23)20-4-2-3-19(25)13-20/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,31)(H,27,30)/t16-/m0/s1
SMILES Code	O=C(N[C@@H](C)CN(CC1)CCC1(N(C2=CC=CC(F)=C2)CN3)C3=O)C4=CC=C(Br)C=C4
References	1) Scott SA, et al Development of a Selective, Allosteric PLD1/2 Inhibitor in a Novel Scaffold. 2012 Apr 5 [updated 2013 Mar 14]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010. 2) O'Reilly MC, et al. Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells. J Med Chem. 2013 Mar 28;56(6):2695-9.