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> Pathway Inhibitors>Enzyme Inhibitors>GGTI-2418

Enzyme Inhibitors

GGTI-2418 View larger

GGTI-2418

AOB15485

CAS: 501010-06-6

 

Chemical Name: GGTI2418; (2S)-2-[[(2S)-2-Benzyl-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxopiperazine-1-carbonyl]amino]-4-methylpentanoic acid

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $41.65 Total: $208.25
110 $35.28 Total: $352.80
125 $29.89 Total: $747.25
150 $25.48 Total: $1,274.00
1100 $22.05 Total: $2,205.00

Data sheet

Molecular FormulaC23H31N5O4
Molecular Weight441.5
CAS Numbers501010-06-6
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymGGTI 2418; GGTI2418
IUPAC/Chemical NameN-[[(2S)-4-[(4-methyl-1H-imidazol-5-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-L-leucine
InChl KeyCOLCNDRDBCLVOC-ICSRJNTNSA-N
InChl CodeInChI=1S/C23H31N5O4/c1-15(2)11-18(22(30)31)26-23(32)28-10-9-27(13-19-16(3)24-14-25-19)21(29)20(28)12-17-7-5-4-6-8-17/h4-8,14-15,18,20H,9-13H2,1-3H3,(H,24,25)(H,26,32)(H,30,31)/t18-,20-/m0/s1
SMILES CodeO=C1[C@H](CC2=CC=CC=C2)N(C(N[C@H](C(O)=O)CC(C)C)=O)CCN1CC3=C(C)N=CN3
References1) Kazi, A., Carie, A., Blaskovich, M.A., et al. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: Implications for breast cancer therapy. Mol. Cell Biol. 29(8), 2254-2263 (2009).

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Novel potent and selective geranylgeranyl transferase I (GGTase I) inhibitor, FBXL2, localization, sensitizer, xenotransplanted, tumours, photodynamic, therapy