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> Pathway Inhibitors>Enzyme Inhibitors>3-Deazaneplanocin A HCl

Enzyme Inhibitors

3-Deazaneplanocin A HCl View larger

3-Deazaneplanocin A HCl

AOB22823

CAS: 120964-45-6

Chemical Name:  (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride

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$208.44

$208.44 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $177.17 Total: $885.87
110 $150.08 Total: $1,500.77
125 $127.15 Total: $3,178.71
150 $108.39 Total: $5,419.44
1100 $93.80 Total: $9,379.80

Data sheet

Molecular FormulaC12H14N4O3.HCl
Molecular Weight298.73
CAS Numbers120964-45-6
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymDZNep,NSC 617989
IUPAC/Chemical Name(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride
InChl KeyUNSKMHKAFPRFTI-FDKLLANESA-N
SMILES CodeOCC([C@@H](O)[C@H]3O)=C[C@H]3N2C=NC1=C(N)N=CC=C12.Cl
References1) Tan et al (2007) Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 21 1050 PMID: 17437993

2) Miranda et al (2009) DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol.Cancer Ther. 8 1579 PMID: 19509260
PubChem ID14563109

More info

3-Deazaneplanocin A hydrochloride is a histone methyltransferase inhibitor; decreases global histone methylation