Enzyme Inhibitors

Lorlatinib View larger

Lorlatinib

AT3061

CAS 1454846-35-5

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$48.00

$48.00 per 5 mg

Data sheet

Molecular FormulaC21H19FN6O2
Molecular Weight406.41
CAS Numbers1454846-35-5
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nn(C)c2C#N
ReferencesJohnson TW, et al. J Med Chem. 2014, 57[11], 4720-4744.

More info

Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity.