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Enzyme Inhibitors
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View larger Zamicastat
AT13383
CAS 1080028-80-3
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $63.75 | Total: $318.75 |
| 1 | 10 | $54.00 | Total: $540.00 |
| 1 | 25 | $45.75 | Total: $1,143.75 |
| 1 | 50 | $39.00 | Total: $1,950.00 |
| 1 | 100 | $33.75 | Total: $3,375.00 |
Data sheet
| Molecular Formula | C21H21F2N3OS |
| Molecular Weight | 401.47 |
| CAS Numbers | 1080028-80-3 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Fc1cc(F)c2OC[C@@H](Cc2c1)n1c(CCNCc2ccccc2)c[nH]c1=S |
| References | Bicker J, et al. In vitro assessment of the interactions of dopamine ?-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein. Eur J Pharm Sci. 2018 May 30;117 35-40. |
More info
Zamicastat (BIA 5-1058) is an inhibitor of dopamine ?-hydroxylase (DBH) and a concentration-dependent dual inhibitor of P-gp and BCRP, with IC50 values of 73.8 ?M and 17.0 ?M, respectively.