Enzyme Inhibitors

BMS493 View larger

BMS493

AT14689

CAS 215030-90-3

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$42.00

$42.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $18.90 Total: $1,890.00
150 $21.84 Total: $1,092.00
125 $25.62 Total: $640.50
110 $30.24 Total: $302.40
15 $35.70 Total: $178.50

Data sheet

Molecular FormulaC29H24O2
Molecular Weight404.5
CAS Numbers215030-90-3
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCC1(C)CC=C(C#Cc2ccccc2)c2cc(C=Cc3ccc(cc3)C(O)=O)ccc12
ReferencesElgamal RM, et al. BMS 493 Modulates Retinoic Acid-Induced Differentiation During Expansion of Human Hematopoietic Progenitor Cells for Islet Regeneration. Stem Cells Dev. 2018 Aug 1;27[15] 1062-1075.

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BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-inhibitors with RARs, attenuates RA signaling, potentiates TPP-induced toxicity, and inhibits the increase in phospholipase A2 activity.