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View larger YAP-TEAD-IN-3
AT77725
CAS 2714434-21-4
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $237.15 | Total: $1,185.75 |
| 1 | 10 | $200.88 | Total: $2,008.80 |
| 1 | 25 | $170.19 | Total: $4,254.75 |
| 1 | 50 | $145.08 | Total: $7,254.00 |
| 1 | 100 | $125.55 | Total: $12,555.00 |
Data sheet
| Molecular Formula | C27H26ClF2N3O4 |
| Molecular Weight | 529.96 |
| CAS Numbers | 2714434-21-4 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C(NC)C1=CN=C(OCCO)C(F)=C1C=2C(Cl)=C(F)C=C3OC(C=4C=CC=CC4)(CC32)C5NCCC5 |
| References | Saunders JT,et al. Targeting the YAP-TEAD interaction interface for therapeutic intervention in glioblastoma. J Neurooncol. 2021 Apr;152[2] 217-231. |
More info
YAP-TEAD-IN-3 is an inhibitor of YAPTAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434). YAP-TEAD-IN-3 inhibits YAP reporter gene expression (IC50 = 0.048 ?M) and NCI-H2052 cell proliferation (IC50 = 0.048 ?M).