Enzyme Inhibitors

VU0359595 View larger

VU0359595

AT21777

CAS 1246303-14-9

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$69.00

$69.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $31.05 Total: $3,105.00
150 $35.88 Total: $1,794.00
125 $42.09 Total: $1,052.25
110 $49.68 Total: $496.80
15 $58.65 Total: $293.25

Data sheet

Molecular FormulaC25H29BrN4O2
Molecular Weight497.43
CAS Numbers1246303-14-9
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1
ReferencesLewis JA, et al. Design and synthesis of isoform-selective phospholipase D [PLD] inhibitors. Part I Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009;19[7] 1916-1920.

More info

VU0359595 (ML-270) is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC50 of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD2 (IC50 of 6.4 ?M). VU0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases.