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View larger TMC647055 Choline Hydroxide Salt
AT21537L
CAS
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $39.15 | Total: $3,915.00 |
| 1 | 50 | $45.24 | Total: $2,262.00 |
| 1 | 25 | $53.07 | Total: $1,326.75 |
| 1 | 10 | $62.64 | Total: $626.40 |
| 1 | 5 | $73.95 | Total: $369.75 |
Data sheet
| Molecular Formula | C37H53N5O8S |
| Molecular Weight | 727.91 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CN(CCOCCN1C)C(C2=CC3=C(C=CC(OC)=C3)C4=C(C5CCCCC5)C(C=CC(C(O)=NS1(=O)=O)=C6)=C6N4C2)=O.OCC[N+](C)(C)C.[OH-] |
| References | Wang H, et al. Molecular modeling study on the drug resistance mechanism of NS5B polymerase to TMC64705Biochem Cell Biol. 2016 Apr;94[2] 147-58. |
More info
TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with minimal associated cell toxicity (CC(50)>20 ?M) and promising pharmacokinetic profiles in rats and dogs. TMC647055 showed promising in vitro biochemical, kinetic, and virological profile that is currently undergoing clinical evaluation.