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Enzyme Inhibitors
- Protein Control Ligand
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- Kinase Inhibitors
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- Synthase
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View larger Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $36.90 | Total: $3,690.00 |
| 1 | 50 | $42.64 | Total: $2,132.00 |
| 1 | 25 | $50.02 | Total: $1,250.50 |
| 1 | 10 | $59.04 | Total: $590.40 |
| 1 | 5 | $69.70 | Total: $348.50 |
Data sheet
| Molecular Formula | C14H10N4S2 |
| Molecular Weight | 298.39 |
| CAS Numbers | 864374-00-5 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC=1N=C(C2=C(NC=N2)C=3C=C4C(=CC3)N=CS4)SC1 |
| References | Naruse T, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-??induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 Jun;69[3] 485-491. |
More info
TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-?-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.