Enzyme Inhibitors

LT?R-IN-1 View larger

LT?R-IN-1

AT11886

CAS 2189366-77-4

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$26.00

$26.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $11.70 Total: $1,170.00
150 $13.52 Total: $676.00
125 $15.86 Total: $396.50
110 $18.72 Total: $187.20
15 $22.10 Total: $110.50

Data sheet

Molecular FormulaC18H16N4O2
Molecular Weight320.35
CAS Numbers2189366-77-4
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC[C@@H](N1Cc2ccccc2C1=O)C(=O)Nc1nc2ccccc2[nH]1
ReferencesHenry KL, Kellner D, Bajrami B, et al. CDK12-mediated transcriptional regulation of noncanonical NF-?B components is essential for signaling. Sci Signal. 2018;11[541] eaam8216.

More info

LT?R-IN-1 is a potent and selective lymphin ? receptor (LT?R) inhibitor with a selective inhibitory effect on the nuclear translocation of p52 of TNF12A, without affecting the nuclear translocation of p65 mediated by the TNF-? receptor. It inhibits p52 nuclear translocation stimulated by TWEAK or Anti-LT?R with an IC50 of 10 ?M and regulates the NF-kB signaling pathway in a ligand-independent manner.