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> Pathway Inhibitors>Enzyme Inhibitors>Telomerase-IN-1

Enzyme Inhibitors

Telomerase-IN-1 View larger

Telomerase-IN-1

AT12009

CAS 666859-49-0

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$70.00

$70.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $59.50 Total: $297.50
110 $50.40 Total: $504.00
125 $42.70 Total: $1,067.50
150 $36.40 Total: $1,820.00
1100 $31.50 Total: $3,150.00

Data sheet

Molecular FormulaC21H23FN2O4
Molecular Weight386.42
CAS Numbers666859-49-0
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCOC(CN1CCC(CC1)C(=O)c1ccc(F)cc1)c1ccc(cc1)[N+]([O-])=O
ReferencesCheng X, et al. Discovery of [4-bromophenyl][3-hydroxy-4-methoxyphenyl]methanone through upregulating hTERT induces cell apoptosis and ERS. Cell Death Dis. 2017;8[8] 3016.

More info

Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 ?M). telomerase-IN-1 activates hTERT expression through the endoplasmic reticulum stress (ERS) of the ER overreaction (EOR), which then induces ERS, leading to apoptosis. telomerase-IN-1 leads to inhibition of cell proliferation through the expression of downstream signaling molecules including Telomease-IN-1 has high inhibitory activity against telomerase, high anti-proliferative capacity against SMMC-7721 cells, and no significant toxic effect on human normal hepatocytes. telomerase-IN-1 in xenograft tumor model exhibited antitumor activity.