Enzyme Inhibitors

LCB 03-0110 dihydrochloride View larger

LCB 03-0110 dihydrochloride

AT32613

CAS 1962928-28-4

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$60.00

$60.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $27.00 Total: $2,700.00
150 $31.20 Total: $1,560.00
125 $36.60 Total: $915.00
110 $43.20 Total: $432.00
15 $51.00 Total: $255.00

Data sheet

Molecular FormulaC24H25Cl2N3O2S
Molecular Weight490.45
CAS Numbers1962928-28-4
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCl.Cl.Oc1cccc(Nc2ccnc3cc(sc23)-c2cccc(CN3CCOCC3)c2)c1
ReferencesSun X, Phan TN, Jung SH, Kim SY, Cho JU, Lee H, Woo SH, Park TK, Yang BS. LCB 03-0110, a novel pan-discoidin domain receptorc-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J Pharmacol Exp Ther. 2012 Mar;340[3] 510-9. doi 10.1124jpet.111.187328. Epub 2011 Nov 29. PMID 22128347.

More info

LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 family. It inhibits LPS-induced activation of macrophages and TGF-?1-induced activation of fibroblasts in vitro, inhibits activation of macrophages and fibroblasts, and inhibits scarring in wound healing models.