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View larger Ac-FLTD-CMK
AT36819
CAS 2376255-48-8
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $214.20 | Total: $1,071.00 |
| 1 | 10 | $181.44 | Total: $1,814.40 |
| 1 | 25 | $153.72 | Total: $3,843.00 |
| 1 | 50 | $131.04 | Total: $6,552.00 |
| 1 | 100 | $113.40 | Total: $11,340.00 |
Data sheet
| Molecular Formula | C26H37ClN4O8 |
| Molecular Weight | 569.05 |
| CAS Numbers | 2376255-48-8 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CCl |
| References | Jie Yang, et al. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A. 2018;115[26] 6792-6797. |
More info
Ac-FLTD-CMK is an inhibitor derived from abscisicin D (GSDMDD) with specific inhibitory effects on inflammatory caspases. ac-FLTD-CMK showed inhibitory effects on caspases-1, caspases-4 and caspases-11 with IC50s of 46.7 nM, 1.49 ?M and 329 nM, respectively. Ac-FLTD-CMK showed potency against caspases-1, caspases-4 and caspases-11, but not against apoptosis-associated caspase-3.