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View larger Cbl-b-IN-3
AT63790
CAS 2573775-59-2
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $277.10 | Total: $1,385.50 |
| 1 | 10 | $234.72 | Total: $2,347.20 |
| 1 | 25 | $198.86 | Total: $4,971.50 |
| 1 | 50 | $169.52 | Total: $8,476.00 |
| 1 | 100 | $146.70 | Total: $14,670.00 |
Data sheet
| Molecular Formula | C30H34F3N5O |
| Molecular Weight | 537.62 |
| CAS Numbers | 2573775-59-2 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CN1C([C@]2(C[C@@H](C)C2)C3=CC(=CC=C3)N4CC=5C(C4=O)=CC(CN6C[C@@H](C)CCC6)=CC5C(F)(F)F)=NN=C1 |
| References | Arthur T., et al. Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof. WO2020264398A1. |
More info
Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ? through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb- -T cell activation.