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Enzyme Inhibitors

Croconazole View larger

Croconazole

AT9878

CAS 77175-51-0

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$44.00

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $37.40 Total: $187.00
110 $31.68 Total: $316.80
125 $26.84 Total: $671.00
150 $22.88 Total: $1,144.00
1100 $19.80 Total: $1,980.00

Data sheet

Molecular FormulaC18H15ClN2O
Molecular Weight310.78
CAS Numbers77175-51-0
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC(=C)(C1=C(OCC2=CC(Cl)=CC=C2)C=CC=C1)N3C=CN=C3
ReferencesLehmann B, et al. Croconazole an inhibitor of eicosanoid synthesis in A23187-stimulated human polymorphonuclear leukocytes and human whole blood. Skin Pharmacol. 1995;8[6] 326-33.

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Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraenoic acid (5-HETE) is 7.8 +- 1.7 and