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> Pathway Inhibitors>Enzyme Inhibitors>ZIP acetate(863987-12-6 free base)

Enzyme Inhibitors

ZIP acetate(863987-12-6 free base) View larger

ZIP acetate(863987-12-6 free base)

ATP1924L1

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$113.00

$113.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $96.05 Total: $480.25
110 $81.36 Total: $813.60
125 $68.93 Total: $1,723.25
150 $58.76 Total: $2,938.00
1100 $50.85 Total: $5,085.00

Data sheet

Molecular FormulaC92H158N30O19
Molecular Weight1988.43
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O.CC(=O)O
ReferencesSerrano et al [2005] Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979 PMID

More info

ZIP acetate is a novel, cell-permeable inhibitor of protein kinase M? (PKM?), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKM?-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 ?M) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.