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View larger S4
AOBS2031
CAS No: 1330061-67-0
Chemical Name: 4-[(3,5-Dimethylphenyl)ureido]phenyl sulfamate
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $15.30 | Total: $76.50 |
| 1 | 10 | $12.96 | Total: $129.60 |
| 1 | 25 | $10.98 | Total: $274.50 |
| 1 | 50 | $9.36 | Total: $468.00 |
| 1 | 100 | $8.10 | Total: $810.00 |
Data sheet
| Molecular Formula | C15H17N3O4S |
| Molecular Weight | 335.38 |
| CAS Numbers | 1330061-67-0 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO 2 mg/mL |
| Purity | 98% by HPLC |
More info
A potent and selective inhibitor against sulfamate carbonic anhydrase (CA) subtypes CAIX & CAXII (Ki = 2, 7, 546, 5600 nM against human CA XII, IX, II, and I, respectively). S4 selectively inhibits migration upon anoxia/hypoxia-induced CAIX expression in cancer cultures (% inhibition/conc./cell line = 54%/100 μM/WRO, 65%/33 μM/MDA-MB-231), while exhibiting no inhibitory effects under normoxia or among non-CAIX-expressing cells (HCT116 & RT112). Daily intraperitoneal injection (10 mg/kg) is reported to reduce the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors in vivo.