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> Pathway Inhibitors>Enzyme Inhibitors>Abiraterone D4A metabolite

Enzyme Inhibitors

Abiraterone D4A metabolite View larger

Abiraterone D4A metabolite

AOBS1963

CAS No: 154229-21-7

Chemical Name: Δ4-abiraterone, 17-(3-Pyridinyl)-androsta-4,16-dien-3-one, Abiraterone ketone analog, D4-abiraterone, D4A  

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $25.08 Total: $125.38
110 $21.24 Total: $212.40
125 $18.00 Total: $449.88
150 $15.34 Total: $767.00
1100 $13.28 Total: $1,327.50

Data sheet

Molecular FormulaC24H29NO
Molecular Weight347.49
CAS Numbers154229-21-7
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSA: 10 mg/mL
Purity98% by HPLC

More info

D4A (Δ4-Abiraterone; 3-Pyridinyl)-androsta-4,16-dien-3-one) is an abiraterone metabolite found to be more active than abiraterone. Abiraterone is a potent, selective, and orally bioavailable inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17 alpha hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition can stop the production of androgens in both places. It is approved for the treatment of metastatic castration-resistant prostate cancer. D4A blocks not only CYP17A1, but also blocks two other enzymes, 3β-hydroxysteroid dehydrogenase (3βHSD) and steroid-5α-reductase (SRD5A), which are involved in producing the androgen 5α-dihydrotestosterone (DHT), while also blocking the androgen receptor