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> G Protein-Coupled Receptor Ligands>Ephrin Receptor>KYL acetate(676657-00-4 free base)

Ephrin Receptor

KYL acetate(676657-00-4 free base) View larger

KYL acetate(676657-00-4 free base)

ATP1895L1

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$113.00

$113.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $96.05 Total: $480.25
110 $81.36 Total: $813.60
125 $68.93 Total: $1,723.25
150 $58.76 Total: $2,938.00
1100 $50.85 Total: $5,085.00

Data sheet

Molecular FormulaC76H112N14O19
Molecular Weight1525.78
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeO=C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC2=CC=C(C=C2)O)NC([C@H]3N(CCC3)C([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)CCCCN)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56.CC(O)=O
ReferencesLamberto et al [2012] Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem. J. 445 47 PMID

More info

KYL acetate is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 ?M); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 ?M). Prevents A?O induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively). Neuroprotective.