Epigenetics

ITF-2357 (Givinostat) View larger

ITF-2357 (Givinostat)

AOB0217

CAS: 732302-99-7

 

Chemical Name: Givinostat; [6-(Diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate Hydrochloride monohydrate

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$19.00

$19.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $8.55 Total: $855.00
150 $9.88 Total: $494.00
125 $11.59 Total: $289.75
110 $13.68 Total: $136.80
15 $16.15 Total: $80.75

Data sheet

Molecular FormulaC24H27N3O4 • HCl [H2O]
Molecular Weight476.0
CAS Numbers732302-99-7
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO and Water
Purity98% by HPLC
IUPAC/Chemical NameN-[4-[(hydroxyamino)carbonyl]phenyl]-carbamic acid, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester, monohydrochloride, monohydrate
InChl KeyFKGKZBBDJSKCIS-UHFFFAOYSA-N
InChl CodeInChI=1S/C24H27N3O4.ClH.H2O/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30;;/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28);1H;1H2
SMILES CodeCC[N+](CC)([H])CC1=CC=C(C=C(COC(NC2=CC=C(C(NO)=O)C=C2)=O)C=C3)C3=C1.[Cl-].O
References1) Leoni, F., Fossati, G., Lewis, E.C., et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Molecular Medicine 11(1-12), 1-15 (2005).

2) Guerini, V., Barbui, V., Spinelli, O., et al. The histone deacetylase inhibitor ITF2357 selectively targets cells bearing mutated JAK2V617F. Leukemia 22, 740-747 (2008

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Orally bioavailable inhibitor of class I and class II HDACs, resulting in an accumulation of highly acetylated histones, inducing chromatin remodeling and an altered pattern of gene expression.

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