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AOB0217
CAS: 732302-99-7
Chemical Name: Givinostat; [6-(Diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate Hydrochloride monohydrate
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Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
---|---|---|---|
1 | 100 | $8.55 | Total: $855.00 |
1 | 50 | $9.88 | Total: $494.00 |
1 | 25 | $11.59 | Total: $289.75 |
1 | 10 | $13.68 | Total: $136.80 |
1 | 5 | $16.15 | Total: $80.75 |
Molecular Formula | C24H27N3O4 • HCl [H2O] |
Molecular Weight | 476.0 |
CAS Numbers | 732302-99-7 |
Storage Condition | 0°C (short term), -20°C (long term), desiccated |
Solubility | DMSO and Water |
Purity | 98% by HPLC |
IUPAC/Chemical Name | N-[4-[(hydroxyamino)carbonyl]phenyl]-carbamic acid, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester, monohydrochloride, monohydrate |
InChl Key | FKGKZBBDJSKCIS-UHFFFAOYSA-N |
InChl Code | InChI=1S/C24H27N3O4.ClH.H2O/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30;;/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28);1H;1H2 |
SMILES Code | CC[N+](CC)([H])CC1=CC=C(C=C(COC(NC2=CC=C(C(NO)=O)C=C2)=O)C=C3)C3=C1.[Cl-].O |
References | 1) Leoni, F., Fossati, G., Lewis, E.C., et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Molecular Medicine 11(1-12), 1-15 (2005). 2) Guerini, V., Barbui, V., Spinelli, O., et al. The histone deacetylase inhibitor ITF2357 selectively targets cells bearing mutated JAK2V617F. Leukemia 22, 740-747 (2008 |
Orally bioavailable inhibitor of class I and class II HDACs, resulting in an accumulation of highly acetylated histones, inducing chromatin remodeling and an altered pattern of gene expression.