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PCI-34051
AOB87225
CAS: 950762-95-5
Chemical Name: N-Hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $6.75 | Total: $675.00 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 5 | $12.75 | Total: $63.75 |
Data sheet
| Molecular Formula | C17H16N2O3 |
| Molecular Weight | 296.32 |
| CAS Numbers | 950762-95-5 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO and Water |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester |
| InChl Key | AJRGHIGYPXNABY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10,21H,11H2,1H3,(H,18,20) |
| SMILES Code | O=C(NO)C1=CC=C2C(N(CC3=CC=C(OC)C=C3)C=C2)=C1 |
| References | 1) Pipalia et al (2011) Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts. Proc.Natl.Acad.Sci.U.S.A. 108 5620 PMID: 21436030 2) Balasubramanian et al (2008) A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. Leukemia 22 1026 PMID: 18256683 |
| PubChem ID | 24753719 |
More info
A potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.