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AOB13811
CAS: 1417997-93-3
Chemical Name: HDAC8-IN-1; (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide
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Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
---|---|---|---|
1 | 100 | $16.65 | Total: $1,665.00 |
1 | 50 | $19.24 | Total: $962.00 |
1 | 25 | $22.57 | Total: $564.25 |
1 | 10 | $26.64 | Total: $266.40 |
1 | 5 | $31.45 | Total: $157.25 |
Molecular Formula | C22H19NO3 |
Molecular Weight | 345.4 |
Storage Condition | 0°C (short term), -20°C (long term), desiccated |
Solubility | DMSO |
Purity | 98% by HPLC |
Synonym | MDK-7933, HDAC8-IN-1 |
IUPAC/Chemical Name | (2E)-N-hydroxy-3-(5-methoxy[1,1′:4′,1′′-terphenyl]-2-yl)-2-propenamide; (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide |
InChl Key | ASHPRZYGCOMVHO-WYMLVPIESA-N |
InChl Code | InChI=1S/C22H19NO3/c1-26-20-13-11-19(12-14-22(24)23-25)21(15-20)18-9-7-17(8-10-18)16-5-3-2-4-6-16/h2-15,25H,1H3,(H,23,24)/b14-12+ |
SMILES Code | COC1=CC=C(/C=C/C(NO)=O)C(C2=CC=C(C3=CC=CC=C3)C=C2)=C1 |
References | 1) Huang, W.-J., Wang, Y.-C., Chao, S.-W., et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors. ChemMedChem 7(10), 1815-1824 (2012). 2) Lin, Fan-Li et al., HDAC8 Inhibitor WK2-16 Therapeutically Targets Lipopolysaccharide-Induced Mouse Model of Neuroinflammation and Microglial Activation, Int J Mol Sci. 2019 Jan; 20(2): 410 |
Novel specific HDAC8 inhibitor, markedly inhibiting LPS-activated STAT-1/-3 and Akt activation, but not NF-κB or MAPK signaling, exhibiting neuroprotective effects through its anti-neuroinflammation and glial inactivation properties, especially in microglia in vitro and in vivo