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Epigenetics

DG-172 dihydrochloride View larger

DG172 dihydrochloride

AOB5825

CAS No: 1361504-77-9

 

Chemical Name: DG172 dihydrochloride; 2-(2-Bromo-phenyl)-3-[4-(4-methyl-piperazin-1-yl)-phenyl]-acrylonitrile dihydrochloride

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$15.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $12.75 Total: $63.75
110 $10.80 Total: $108.00
125 $9.15 Total: $228.75
150 $7.80 Total: $390.00
1100 $6.75 Total: $675.00

Data sheet

Molecular FormulaC20H22BrCl2N3
Molecular Weight455.22
CAS Numbers1361504-77-9
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name2-bromo-αZ-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]-benzeneacetonitrile, dihydrochloride
InChl KeySABUORLIDVBCPI-WTLOABTRSA-N
InChl CodeInChI=1S/C20H20BrN3.2ClH/c1-23-10-12-24(13-11-23)18-8-6-16(7-9-18)14-17(15-22)19-4-2-3-5-20(19)21;;/h2-9,14H,10-13H2,1H3;2*1H/b17-14+;;
SMILES CodeCN1CCN(C2=CC=C(/C=C(C#N)/C3=C(Br)C=CC=C3)C=C2)CC1.Cl.Cl
References1) Lieber, S., Scheer, F., Meissner, W., et al. (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): An orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. J. Med. Chem. 55(6), 2858-2868 (2012).

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Orally available potent PPARß/d inverse agonist, inhibiting Angptl4 gene expression and augmenting GM-CSF/IL-4-induced differentiation of mature dendritic cells from bone marrow cells in culture