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Epigenetics

EPZ-719 View larger

EPZ-719

AOB12228

CAS: 2697176-16-0

 

Chemical Name: 4-Fluoro-7-methyl-N-((1R,3S)-3-((S)-3-(N-methylmethylsulfonamido)pyrrolidin-1-yl)cyclohexyl)-1H-indole-2-carboxamide

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$119.00

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $101.15 Total: $505.75
110 $85.68 Total: $856.80
125 $72.59 Total: $1,814.75
150 $61.88 Total: $3,094.00
1100 $53.55 Total: $5,355.00

Data sheet

Molecular FormulaC22H31FN4O3S
Molecular Weight450.57
CAS Numbers2697176-16-0 (free base)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymEPZ-719; EPZ719; EPZ 719;
IUPAC/Chemical Name4-fluoro-7-methyl-N-((1R,3S)-3-((S)-3-(N-methylmethylsulfonamido)pyrrolidin-1-yl)cyclohexyl)-1H-indole-2-carboxamide
InChl KeyZLVKIBLQXFILMA-IKGGRYGDSA-N
InChl CodeInChI=1S/C22H31FN4O3S/c1-14-7-8-19(23)18-12-20(25-21(14)18)22(28)24-15-5-4-6-16(11-15)27-10-9-17(13-27)26(2)31(3,29)30/h7-8,12,15-17,25H,4-6,9-11,13H2,1-3H3,(H,24,28)/t15-,16+,17+/m1/s1
SMILES Code O=C(C(N1)=CC2=C1C(C)=CC=C2F)N[C@H]3C[C@@H](N4C[C@@H](N(C)S(=O)(C)=O)CC4)CCC3
References1) Lampe JW, Alford JS, Boriak-Sjodin PA, Brach D, Cosmopoulos K, Duncan KW, Eckley ST, Foley MA, Harvey DM, Motwani V, Munchhof MJ, Raimondi A, Riera TV, Tang C, Thomenius MJ, Totman J, Farrow NA. Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies. ACS Med Chem Lett. 2021 Aug 24;12(10):1539-1545. doi: 10.1021/acsmedchemlett.1c00272. PMID: 34671445; PMCID: PMC8521618.

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First-in-Class Inhibitor of the Histone Methyltransferase SETD2 with a high selectivity over other histone methyltransferases