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Epigenetics
- Protein Control Ligand
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ACY-1215
AOB87408
Molarity Calculation Cart®
HOW TO ORDER
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $4.95 | Total: $495.00 |
| 1 | 50 | $5.72 | Total: $286.00 |
| 1 | 25 | $6.71 | Total: $167.75 |
| 1 | 10 | $7.92 | Total: $79.20 |
| 1 | 5 | $9.35 | Total: $46.75 |
Data sheet
| Molecular Formula | C24H27N5O3 |
| Molecular Weight | 433.5 |
| CAS Numbers | 1316214-52-4 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMF: 5 mg/ml DMSO: 5 mg/ml DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml |
| Purity | 99.5% by HPLC |
| Synonym | ACY-63 |
| IUPAC/Chemical Name | 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide |
| InChl Key | QGZYDVAGYRLSKP-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30) |
| SMILES Code | O=C(NCCCCCCC(NO)=O)C(C=N1)=CN=C1N(C2=CC=CC=C2)C3=CC=CC=C3 |
| References | 1) Santo, L., Hideshima, T., Kung, A.L., et al. Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma. Blood 119(11), 2579-2589 (2012). 2) Amengual, J.E., Johannet, P., Lombardo, M., et al. Dual targeting of protein degradation pathways with the selective HDAC6 inhibitor ACY-1215 and bortezomib is synergistic in lymphoma. Clin. Cancer Res. 21(20), 4663-4675 (2015). |
More info
An orally bioavailable HDAC6-selective inhibitor against HDAC4, HDAC5, HDAC7, HDAC9, HDAC11, Sirtuin1, and Sirtuin2
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