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View larger KDM5A-IN-1
AT15650
CAS 1905481-36-8
1000 Items
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $107.95 | Total: $539.75 |
| 1 | 10 | $91.44 | Total: $914.40 |
| 1 | 25 | $77.47 | Total: $1,936.75 |
| 1 | 50 | $66.04 | Total: $3,302.00 |
| 1 | 100 | $57.15 | Total: $5,715.00 |
Data sheet
| Molecular Formula | C15H22N4O2 |
| Molecular Weight | 290.36 |
| CAS Numbers | 1905481-36-8 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)NC(=O)C1CC1 |
| References | Liang J, et al. From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. Bioorg Med Chem Lett. 2017 Jul 1;27[13] 2974-2981. |
More info
KDM5A-IN-1 is an orally available, potent and selective inhibitor of the pan-histidine lysine demethylase 5 KDM5, inhibiting KDM5A, KDM5B, and KDM5C with IC50 values of 45 nM, 56 nM, and 55 nM, respectively.KDM5A-IN-1 inhibits PC9 H3K4Me3, and may be useful in cancer research.