Epigenetics

UNC0321 View larger

UNC0321

AT17204

CAS 1238673-32-9

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$33.00

$33.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $14.85 Total: $1,485.00
150 $17.16 Total: $858.00
125 $20.13 Total: $503.25
110 $23.76 Total: $237.60
15 $28.05 Total: $140.25

Data sheet

Molecular FormulaC27H45N7O3
Molecular Weight515.69
CAS Numbers1238673-32-9
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCOc1cc2c(NC3CCN(C)CC3)nc(nc2cc1OCCOCCN(C)C)N1CCCN(C)CC1
ReferencesLiu F, et al. Protein lysine methyltransferase G9a inhibitors design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53[15] 5844-57.

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UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.