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Quizartinib View larger

Quizartinib

SKP3266

CAS No:950769-58-1

Chemical Name: AC-220; 1-(5-tert-Butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $38.25 Total: $191.25
110 $32.40 Total: $324.00
125 $27.45 Total: $686.25
150 $23.40 Total: $1,170.00
1100 $20.25 Total: $2,025.00

Data sheet

Molecular FormulaC29H32N6O4S
Molecular Weight560.67
CAS Numbers950769-58-1
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymAC220; AC 220; AC-220; AC010220; AC-010220; AC 010220; AC010220; Quizartinib
IUPAC/Chemical Name1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea
InChl KeyInChi Key: CVWXJKQAOSCOAB-UHFFFAOYSA-N
InChl CodeInChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
SMILES CodeO=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C(C)(C)C)=C6
References1) Smith CC, etc. Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. Cancer Discov. 2015 Jun;5(6):668-79.

2) Zorn JA, Wang Q, Fujimura E, Barros T, Kuriyan J. Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220). PLoS One. 2015 Apr 2;10(4):e0121177.

3: Altman K, Sharata H. Catastrophic eruptive keratoacanthomas and squamous cell cancers after treatment with an FLT3 inhibitor quizartinib (AC220). Dermatol Surg. 2015 Apr;41(4):530-1

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A second-generation FLT3 inhibitor that has shown promising activity in AML in Phase II clinical trials