Function Modulators

ARS-1620 View larger

ARS-1620

AOB17705

CAS: 1698055-85-4

 

Chemical Name: (S)-1-(4-(6-Chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one

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$49.00

$49.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $22.05 Total: $2,205.00
50 $25.48 Total: $1,274.00
25 $29.89 Total: $747.25
10 $35.28 Total: $352.80
5 $41.65 Total: $208.25

Data sheet

Molecular FormulaC21H17ClF2N4O2
Molecular Weight430.84
CAS Numbers1698055-85-4
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilitySoluble to in DMSO
Purity98% by HPLC
SynonymARS-1620; ARS 1620; ARS1620
IUPAC/Chemical Name (S)-1-(4-(6-Chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
InChl KeyZRPZPNYZFSJUPA-UHFFFAOYSA-N
InChl CodeInChI=1S/C21H17ClF2N4O2/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17(19(24)20(12)25-11-26-21)18-14(23)4-3-5-15(18)29/h2-5,10-11,29H,1,6-9H2
SMILES CodeC=CC(N1CCN(C2=C3C=C(Cl)[C@@]([C@@]4=C(O)C=CC=C4F)=C(F)C3=NC=N2)CC1)=O.[S]
References1) Hansen R, Peters U, Babbar A, Chen Y, Feng J, Janes MR, Li LS, Ren P, Liu Y, Zarrinkar PP. The reactivity-driven biochemical mechanism of covalent KRAS(G12C) inhibitors. Nat Struct Mol Biol. 2018 May 14. doi: 10.1038/s41594-018-0061-5

2) Janes MR, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 2018 Jan 25;172(3):578-589.e17

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Novel atropisomeric selective KRASG12C inhibitor