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Ponesimod

AOB37099

CAS: 854107-55-4

 

Chemical Name: ACT-128800; (2Z,5Z)-5-{3-Chloro-4-[(2R)-2,3-dihydroxypropoxy]benzylidene}-3-(2-methylphenyl)-2-(propylimino)-1,3-thiazolidin-4-one

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $21.25 Total: $106.25
110 $18.00 Total: $180.00
125 $15.25 Total: $381.25
150 $13.00 Total: $650.00
1100 $11.25 Total: $1,125.00

Data sheet

Molecular FormulaC23H25ClN2O4S
Molecular Weight460.97
CAS Numbers854107-55-4
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymACT-128800; ACT 128800; ACT128800; Ponesimod.
IUPAC/Chemical Name (Z)-5-((Z)-3-chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one
InChl KeyLPAUOXUZGSBGDU-STDDISTJSA-N
InChl CodeInChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m1/s1
SMILES CodeO=C1N(C2=CC=CC=C2C)/C(S/C1=CC3=CC=C(OC[C@H](O)CO)C(Cl)=C3)=N/CCC
References1) Juif PE, Hoch M, D'Ambrosio D, Dingemanse J. Biocomparison of Three Formulations of the S1P1 Receptor Modulator Ponesimod in Healthy Subjects. Drugs R D. 2015 Jun;15(2):203-10. doi: 10.1007/s40268-015-0095-7. PubMed PMID: 25939333; PubMed Central PMCID: PMC4488184.

2) Scherz MW, Brossard P, D'Ambrosio D, Ipek M, Dingemanse J. Three different up-titration regimens of ponesimod, an S1P1 receptor modulator, in healthy subjects. J Clin Pharmacol. 2015 Jun;55(6):688-97. doi: 10.1002/jcph.467. Epub 2015 Feb 10. PubMed PMID: 25612299.

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