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Ponesimod
AOB37099
CAS: 854107-55-4
Chemical Name: ACT-128800; (2Z,5Z)-5-{3-Chloro-4-[(2R)-2,3-dihydroxypropoxy]benzylidene}-3-(2-methylphenyl)-2-(propylimino)-1,3-thiazolidin-4-one
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $11.25 | Total: $1,125.00 |
| 1 | 50 | $13.00 | Total: $650.00 |
| 1 | 25 | $15.25 | Total: $381.25 |
| 1 | 10 | $18.00 | Total: $180.00 |
| 1 | 5 | $21.25 | Total: $106.25 |
Data sheet
| Molecular Formula | C23H25ClN2O4S |
| Molecular Weight | 460.97 |
| CAS Numbers | 854107-55-4 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | ACT-128800; ACT 128800; ACT128800; Ponesimod. |
| IUPAC/Chemical Name | (Z)-5-((Z)-3-chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one |
| InChl Key | LPAUOXUZGSBGDU-STDDISTJSA-N |
| InChl Code | InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m1/s1 |
| SMILES Code | O=C1N(C2=CC=CC=C2C)/C(S/C1=CC3=CC=C(OC[C@H](O)CO)C(Cl)=C3)=N/CCC |
| References | 1) Juif PE, Hoch M, D'Ambrosio D, Dingemanse J. Biocomparison of Three Formulations of the S1P1 Receptor Modulator Ponesimod in Healthy Subjects. Drugs R D. 2015 Jun;15(2):203-10. doi: 10.1007/s40268-015-0095-7. PubMed PMID: 25939333; PubMed Central PMCID: PMC4488184. 2) Scherz MW, Brossard P, D'Ambrosio D, Ipek M, Dingemanse J. Three different up-titration regimens of ponesimod, an S1P1 receptor modulator, in healthy subjects. J Clin Pharmacol. 2015 Jun;55(6):688-97. doi: 10.1002/jcph.467. Epub 2015 Feb 10. PubMed PMID: 25612299. |
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Novel potent selective sphingosine-1-phosphate receptor 1 modulator