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ABBV-167
AOB12388
CAS: 1351456-78-4
Chemical Name: (5-(5-(4-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-2-(((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)carbamoyl)phenoxy)-7H-pyrrolo[2,3-b]pyridin-7-yl)methyl dihydrogen phosphate
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $31.05 | Total: $3,105.00 |
| 1 | 50 | $35.88 | Total: $1,794.00 |
| 1 | 25 | $42.09 | Total: $1,052.25 |
| 1 | 10 | $49.68 | Total: $496.80 |
| 1 | 5 | $58.65 | Total: $293.25 |
Data sheet
| Molecular Formula | C46H53ClN7O11PS |
| Molecular Weight | 978.45 |
| CAS Numbers | 1351456-78-4 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | Prodrug |
| IUPAC/Chemical Name | (5-(5-(4-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-2-(((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)carbamoyl)phenoxy)-7H-pyrrolo[2,3-b]pyridin-7-yl)methyl dihydrogen phosphate |
| SMILES Code | CC1(CCC(CN2CCN(CC2)C3=CC(OC4=CN(C5=NC=CC5=C4)COP(O)(O)=O)=C(C=C3)C(NS(=O)(C6=CC([N+]([O-])=O)=C(C=C6)NCC7CCOCC7)=O)=O)=C(C1)C8=CC=C(C=C8)Cl)C |
| References | 1) Salem AH, et al. Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers. Mol Cancer Ther. 2021 Jun;20(6):999-1008. |
More info
Novel phosphate prodrug of the BCL-2 inhibitor venetoclax (AOB5080)