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> G Protein-Coupled Receptor Ligands>ATC0065

G Protein-Coupled Receptor Ligands

ATC0065 View larger

ATC0065

AOB37801

CAS No: 510732-84-0 (free base: 509145-82-8)

 

Chemical Name: N2-(cis-4-((4-Bromo-2-(trifluoromethoxy)phenethyl)amino)cyclohexyl)-N4,N4-dimethylquinazoline-2,4-diamine Dihydrochloride

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $17.85 Total: $89.25
110 $15.12 Total: $151.20
125 $12.81 Total: $320.25
150 $10.92 Total: $546.00
1100 $9.45 Total: $945.00

Data sheet

Molecular FormulaC25H31BrCl2F3N5O
Molecular Weight625.36
CAS Numbers510732-84-0 (free base: 509145-82-8)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity95% by HPLC
SynonymATC0065; ATC 0065; ATC-0065
IUPAC/Chemical NameN2-[cis-4-[[2-[4-Bromo-2-(trifluoromethoxy)phenyl]ethyl]amino]cyclohexyl]-N4,N4-dimethyl-2,4-quinazolinediamine dihydrochloride
InChl KeyBPGUWYBAINNZQH-LFOVFOEYSA-N
InChl CodeInChI=1S/C25H29BrF3N5O.2ClH/c1-34(2)23-20-5-3-4-6-21(20)32-24(33-23)31-19-11-9-18(10-12-19)30-14-13-16-7-8-17(26)15-22(16)35-25(27,28)29;;/h3-8,15,18-19,30H,9-14H2,1-2H3,(H,31,32,33);2*1H/t18-,19+;;
SMILES CodeCN(C)C1=C2C=CC=CC2=NC(N[C@H]3CC[C@@H](NCCC4=CC=C(Br)C=C4OC(F)(F)F)CC3)=N1.[H]Cl.[H]Cl
References1) Kanuma K, Omodera K, Nishiguchi M, Funakoshi T, Chaki S, Nagase Y, Iida I, Yamaguchi J, Semple G, Tran TA, Sekiguchi Y. Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem. 2006 May 15;14(10):3307-19. PubMed PMID: 16434202.

2) Chaki S, Funakoshi T, Hirota-Okuno S, Nishiguchi M, Shimazaki T, Iijima M, Grottick AJ, Kanuma K, Omodera K, Sekiguchi Y, Okuyama S, Tran TA, Semple G, Thomsen W. Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J Pharmacol Exp Ther. 2005 May;313(2):831-9. PubMed PMID: 15677346.

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Novel nonpeptidic and orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist