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AOB37801
CAS No: 510732-84-0 (free base: 509145-82-8)
Chemical Name: N2-(cis-4-((4-Bromo-2-(trifluoromethoxy)phenethyl)amino)cyclohexyl)-N4,N4-dimethylquinazoline-2,4-diamine Dihydrochloride
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Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
---|---|---|---|
1 | 100 | $9.45 | Total: $945.00 |
1 | 50 | $10.92 | Total: $546.00 |
1 | 25 | $12.81 | Total: $320.25 |
1 | 10 | $15.12 | Total: $151.20 |
1 | 5 | $17.85 | Total: $89.25 |
Molecular Formula | C25H31BrCl2F3N5O |
Molecular Weight | 625.36 |
CAS Numbers | 510732-84-0 (free base: 509145-82-8) |
Storage Condition | 0°C (short term), -20°C (long term), desiccated |
Solubility | DMSO |
Purity | 95% by HPLC |
Synonym | ATC0065; ATC 0065; ATC-0065 |
IUPAC/Chemical Name | N2-[cis-4-[[2-[4-Bromo-2-(trifluoromethoxy)phenyl]ethyl]amino]cyclohexyl]-N4,N4-dimethyl-2,4-quinazolinediamine dihydrochloride |
InChl Key | BPGUWYBAINNZQH-LFOVFOEYSA-N |
InChl Code | InChI=1S/C25H29BrF3N5O.2ClH/c1-34(2)23-20-5-3-4-6-21(20)32-24(33-23)31-19-11-9-18(10-12-19)30-14-13-16-7-8-17(26)15-22(16)35-25(27,28)29;;/h3-8,15,18-19,30H,9-14H2,1-2H3,(H,31,32,33);2*1H/t18-,19+;; |
SMILES Code | CN(C)C1=C2C=CC=CC2=NC(N[C@H]3CC[C@@H](NCCC4=CC=C(Br)C=C4OC(F)(F)F)CC3)=N1.[H]Cl.[H]Cl |
References | 1) Kanuma K, Omodera K, Nishiguchi M, Funakoshi T, Chaki S, Nagase Y, Iida I, Yamaguchi J, Semple G, Tran TA, Sekiguchi Y. Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem. 2006 May 15;14(10):3307-19. PubMed PMID: 16434202. 2) Chaki S, Funakoshi T, Hirota-Okuno S, Nishiguchi M, Shimazaki T, Iijima M, Grottick AJ, Kanuma K, Omodera K, Sekiguchi Y, Okuyama S, Tran TA, Semple G, Thomsen W. Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J Pharmacol Exp Ther. 2005 May;313(2):831-9. PubMed PMID: 15677346. |
Novel nonpeptidic and orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist