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View larger BI-749327
AOB13765
CAS: 2361241-23-6
Chemical Name: (4-(6-Aminopyridazin-3-yl)piperidin-1-yl)(4-(4-(trifluoromethyl)phenoxy)phenyl)methanone
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $16.15 | Total: $80.75 |
| 1 | 10 | $13.68 | Total: $136.80 |
| 1 | 25 | $11.59 | Total: $289.75 |
| 1 | 50 | $9.88 | Total: $494.00 |
| 1 | 100 | $8.55 | Total: $855.00 |
Data sheet
| Molecular Formula | C23H21F3N4O2 |
| Molecular Weight | 442.44 |
| CAS Numbers | CAS: 2361241-23-6 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | BI749327, BI 749327 |
| IUPAC/Chemical Name | (4-(6-Aminopyridazin-3-yl)piperidin-1-yl)(4-(4-(trifluoromethyl)phenoxy)phenyl)methanone |
| SMILES Code | NC1=NN=C(C2CCN(C(C3=CC=C(OC4=CC=C(C(F)(F)F)C=C4)C=C3)=O)CC2)C=C1 |
| References | 1) Lin B L, et al. In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease. Proc Natl Acad Sci U S A. 2019 May 14;116(20):10156-10161. |
More info
Novel potent and selective orally bioavailable TRPC6 antagonist with 85- and 42-fold selectivity over the most closely related channels, TRPC3 and TRPC7