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> G Protein-Coupled Receptor Ligands>OPC-21268

G Protein-Coupled Receptor Ligands

OPC-21268 View larger

OPC-21268

AOB6575

CAS: 131631-89-5

 

Chemical Name: N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $17.85 Total: $89.25
110 $15.12 Total: $151.20
125 $12.81 Total: $320.25
150 $10.92 Total: $546.00
1100 $9.45 Total: $945.00

Data sheet

Molecular FormulaC26H31N3O4
Molecular Weight449.55
CAS Numbers131631-89-5
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO and Alcohol
Purity98% by HPLC
SynonymOPC-21268; OPC21268; OPC 21268
IUPAC/Chemical NameN-(3-(4-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidine-1-carbonyl)phenoxy)propyl)acetamide
InChl KeyKSNUCNRMDYJBKT-UHFFFAOYSA-N
InChl CodeInChI=1S/C26H31N3O4/c1-19(30)27-15-4-18-33-23-10-7-21(8-11-23)26(32)28-16-13-22(14-17-28)29-24-6-3-2-5-20(24)9-12-25(29)31/h2-3,5-8,10-11,22H,4,9,12-18H2,1H3,(H,27,30)
SMILES CodeCC(NCCCOC1=CC=C(C(N2CCC(N3C(CCC4=C3C=CC=C4)=O)CC2)=O)C=C1)=O
References1) Shinoura H, Take H, Itoh S, Hirasawa A, Inoue K, Ohno Y, Hashimoto K, Tsujimoto G. Key amino acids of vasopressin V1a receptor responsible for the species difference in the affinity of OPC-21268. FEBS Lett. 2000 Jan 28;466(2-3):255-8. Erratum in: FEBS Lett 2000 Jun 2;474(2-3):257. PubMed PMID: 10682838.

2) Sugimoto I, Narimiya N, Odagiri M, Ohnishi A, Tanaka T. Protective effect of a vasopressin-1 selective antagonist, OPC-21268, against ethanol-induced damage of the rat gastric wall. Dig Dis Sci. 1999 Mar;44(3):503-9. PubMed PMID: 10080141.

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Nonpeptide vasopressin V1 receptor antagonist